LABORATOIRE DE PHYSIQUE THEORIQUE DE LA MATIERE CONDENSEE




 

Annie Lemarchand Fraikin

Directrice de recherche au CNRS

Habilitée à diriger des recherches

 

Contact

Université Pierre et Marie Curie

Laboratoire de Physique Théorique de la Matière Condensée – CNRS UMR 7600

4 place Jussieu, case courrier 121

75252 Paris cedex 05, FRANCE

 

Corridor 13-23, 5th floor, room 507

Tel: 33 (0)1 44 27 44 55

Fax: 33 (0)1 44 27 51 00

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

 

Research domain

 

Multiscale description of far-from-equilibrium chemical systems

 

At the interface between statistical physics, dynamical systems applied to chemistry, and materials science, my research activities concentrate on the multiscale study of the dynamics and structure of far-from-equilibrium reactive systems.

 

The following issues are presently investigated:

 

- Modeling of somitogenesis (formation of prevertebrae) using Turing-like structures at the macroscopic, mesoscopic and microscopic scales. Emphasis is given on the constructive role of internal fluctuations,

 

- Modeling of cell interactions in the framework of thermostatted kinetic theory with application to the interactions between cancer cells and immune-system cells,

 

- Kinetic Monte Carlo simulations of plaster hydration and gypsum precipitation : development of a predictive tool in order to rationalize the choice of additives and the optimization of material properties,

 

- In collaboration with experimentalists in microfluidics, design of non-invasive methods of

(i) determination of chemical mechanisms and rate constants for chemical and biological reaction networks,

(ii) distinction between a nonequilibrium steady state and an equilibrium state.

 

Evaluation of the departure from equilibrium at cell scale

Carlo Bianca and Annie Lemarchand

J. Chem. Phys. 141, 144102 (2014), Physica A 438, 1 (2015)

 

The complex spatio-temporal structures that appear in biological systems require far-from equilibrium conditions which lead to the circulation of reaction fluxes. Recent developments in nonequilibrium statistical physics propose a theoretical framework for estimating these reaction fluxes. In particular, the time asymmetry of fluctuations could be a priori exploited. Fluorescence imaging gives directly access to the observation of the dynamics of cell events. The temporal ordering of three proteins in the endocytic pathway has been extracted and reaction flux has been estimated for an assumed mechanism with linear dynamics [D. R. Sisan, D. Yarar, C. M. Waterman, and J. S. Urbach, Biophys. J. 98, 2432 (2010)]. However, endocytosis is known to involve complex regulation mechanisms and our aim is to warn against the blind use of the simple relation between reaction flux and cross-correlation function of concentration fluctuations found for linear deterministic dynamics [W. J. Heuett and H. Qian, J. Chem. Phys. 124, 044110 (2006)].

 

In the biologically relevant case of a reactive system which may admit periodic oscillations, our results show that the amplitude of the cross-correlation functions is not only proportional to the reaction flux but also to a specific parameter-dependent function which diverges as a Hopf bifurcation approaches. In order to harvest the determination of correlation functions for reaction flux estimation in a given chemical system, it is therefore essential first to identify the reaction mechanism and secondly to evaluate the associated rate constants. If these demanding requirements may be fulfilled, the stochastic differential equations of Langevin type governing the fluctuating dynamics of concentrations provide a reliable, analytical formula relating the reaction flux and the correlations of fluctuations. From the theoretical viewpoint, the interplay between fluctuations and nonlinearities of deterministic dynamics is subtle and leads to specific formulas for the time cross-correlations of concentration fluctuations, that depend on the details of dynamics.

 

 

Publications

 

C. Bianca and A. Lemarchand,

Miming the cancer-immune system competition by kinetic Monte Carlo simulations,

J. Chem. Phys. to appear.

 

L. Signon, B. Nowakowski, and A. Lemarchand,

Modelling somite scaling in small embryos in the framework of Turing patterns,

Phys. Rev. E 93, 042402 (2016).

 

J. Quérard, T. Le Saux, A. Gautier, D. Alcor, V. Croquette, C. Gosse, A. Lemarchand, and L. Jullien,

Kinetics of reactive modules adds discriminative dimensions for selective cell imaging,

ChemPhysChem 17, 1396 (2016).

 

J. Gorecki, B. Nowakowski, J. N. Gorecka, and A. Lemarchand,

Minimum size for a nanoscale temperature discriminator based on a thermochemical system,

Phys. Chem. Chem. Phys. 18, 4952 (2016).

 

C. Bianca and A. Lemarchand,

From cellular to tissue scales by asymptotic limits of thermostatted kinetic models,

Eur. Phys. J. Plus 131, 41 (2016).

 

C. Bianca and A. Lemarchand,

Evaluation of reaction fluxes in stationary and oscillating far-from-equilibrium biological systems,

Physica A 438, 1 (2015).

 

F. Closa, C. Gosse, L. Jullien, and A. Lemarchand,

Identication of two-step chemical mechanisms using small temperature oscillations and a single tagged species,

J. Chem. Phys. 142, 174108 (2015).

 

C. Bianca, C. Dogbe, and A. Lemarchand,

Onset of hyperbolic macroscopic behavior in complex systems subjected to external agents,

Appl. Math. Inf. Sci. 9, 2477 (2015).

 

C. Bianca and A. Lemarchand,

Density evolution by the low-field limit of kinetic frameworks with thermostat and mutations,

Commun. Nonlinear Sci. Numer. Simulat. 20, 14 (2015).

 

C. Bianca, C. Dogbe, and A. Lemarchand,

The role of nonconservative interactions in the asymptotic limit of thermostatted kinetic models,

Acta Appl. Math. 139, 1 (2015).

 

S. Joiret, F. Pillier, and A. Lemarchand,

Submicrometric Picture of Plaster Hydration: Dynamic and Space-Resolved Raman Spectroscopy versus Kinetic Monte Carlo Simulations,

J. Phys. Chem. C 118, 28730 (2014).

 

C. Bianca, L. Guerrini, and A. Lemarchand,

Existence of solutions of a partial integro-differential equation with thermostat and time delay,

Abstract and Applied Analysis 2014, 463409 (2014).

 

C. Bianca and A. Lemarchand,

Determination of reaction flux from concentration fluctuations near a Hopf bifurcation,

J. Chem. Phys. 141, 144102 (2014).

 

C. Bianca and A. Lemarchand,

Temporal cross-correlation asymmetry and departure from equilibrium in a bistable chemical system,

J Chem. Phys. 140, 224105 (2014).

 

C. Bianca and A. Lemarchand,

A Kinetic Framework for Modeling Nonequilibrium Biological and Chemical Systems,

Nonlinear Stud. 21, 367 (2014).

 

A. Lemarchand, J. Gorecki, A. Gorecki, and B. Nowakowski,

Temperature driven coherence resonance and stochastic resonance in a thermochemical system,

Phys. Rev. E 89, 022916 (2014).

 

P. Dziekan, L. Signon, B. Nowakowski, and A. Lemarchand,

Effect of a local source or sink of inhibitor on Turing patterns,

Commun. Theor. Phys. 62, 622 (2014).

 

P. Dziekan, B. Nowakowski, and A. Lemarchand,

Reaction-diffusion scheme for the clock and wavefront mechanism of pattern formation,

Eur. Phys. J. B 87, 77 (2014).

 

J. Gorecki, A. Gorecki, A. Lemarchand, and B. Nowakowski,

Information resonance in a model excitable system,

Eur. Phys. J. B 86, 264 (2013).

 

P. Dziekan, L. Signon, B. Nowakowski, and A. Lemarchand,

Reaction-diffusion approach to prevertebrae formation: Effect of a local source of morphogen,

J Chem. Phys. 139, 114107 (2013).

 

F. Closa, C. Gosse, L. Jullien, and A. Lemarchand,

Identification of Two-Step Chemical Mechanisms and Determination of Thermokinetic Parameters using Frequency Responses to Small Temperature Oscillations,

J Chem. Phys. 138, 244109 (2013).

 

C. Antoine, G. Dumazer, B. Nowakowski, and A. Lemarchand,

Nonlinear hydrodynamic corrections to supersonic F-KPP wave fronts,

Physica D 241, 461 (2012).

 

P. Dziekan, A. Lemarchand, and B. Nowakowski,

Master equation for a bistable chemical system with perturbed particle velocity distribution function,

Phys. Rev E 85, 021128 (2012).

 

A. Lemarchand, F. Boudoire, E. Boucard, T. Chotard, and A. Smith,

Plaster hydration at different plaster-to-water ratios: Acoustic emission and 3-dimensional submicrometric simulations,

J. Phys. Chem. C 116, 4671 (2012).

 

A. Lemarchand, H. Berthoumieux, L. Jullien, and C. Gosse,

Chemical mechanism identification from frequency response to small temperature modulation,

J. Phys. Chem. A 116, 8455 (2012).

 

P. Dziekan, A. Lemarchand, and B. Nowakowski,

Particle dynamics simulations of Turing patterns,

J. Chem. Phys. 137, 074107 (2012).

 

P. Dziekan, B. Nowakowski, and A. Lemarchand,

Master equation for a chemical wave front with perturbation of local equilibrium,

J. Chem. Phys. 135, 084123 (2011).

Selected by the Virtual Journal of Nanoscale Science & Technology, Sept. 12, Vol. 24(11), 2011.

 

K. Zrelli, T. Barilero, H. Berthoumieux, T. Le Saux, C. Gosse, A. Lemarchand and L. Jullien,

Kinetic and Thermodynamic Characterisation by Heating in a Microfluidic Cell,

Sensor Lett. 9, 2332 (2011).

 

A. Lemarchand, B. Nowakowski, G. Dumazer, and C. Antoine,

Microscopic simulations of supersonic and subsonic exothermic chemical wave fronts and transition to detonation,

J. Chem. Phys. 134, 034121 (2011).

 

K. Zrelli, T. Barilero, E. Cavatore, H. Berthoumieux, T. Le Saux, V. Croquette, A. Lemarchand, C. Gosse, and L. Jullien,

Temperature modulation and quadrature detection for selective titration of two-state exchanging reactants,

Anal. Chem. 83, 2476 (2011).

 

A. Lemarchand and B. Nowakowski,

Do the internal fluctuations blur or enhance axial segmentation?,

EuroPhysics Letters 94, 48004 (2011).

 

B. Nowakowski, A. L. Kawczynski, A. Kolbus, and A. Lemarchand,

Coherence resonances in excitable thermochemical systems induced by scaled reaction heat,

Eur. Phys. J. B 84, 137 (2011).

 

G. Dumazer, A. Smith, and A. Lemarchand,

Master equation approach to gypsum needle crystallization,

J. Phys. Chem. C 114, 3830 (2010).

 

A. Kolbus, A. Lemarchand, A. Kawczynski, and B. Nowakowski,

Coherence resonances in an excitable thermochemical system with multiple stationary states,

Phys. Chem. Chem. Phys. 12, 13224 (2010).

 

G. Dumazer, V. Narayan, A. Smith, and A. Lemarchand,

Modeling gypsum crystallization on a submicrometric scale,

J. Phys. Chem. C 113, 1189 (2009).

 

H. Berthoumieux, C. Antoine, L. Jullien, and A. Lemarchand,

Resonant Response to Temperature Modulation for Enzymatic Dynamics Characterization,

Phys. Rev. E 79, 021906 (2009).

Selected by the Virtual Journal of Biological Physics Research, Feb. 15, Vol. 17(4), 2009.

 

H. Berthoumieux, C. Antoine, and A. Lemarchand,

Determination of the six rate constants of a three-state enzymatic network and a noninvasive test of detailed balance,

J. Chem. Phys. 131, 084106 (2009).

Selected by the Virtual Journal of Biological Physics Research, Sep. 1, Vol. 18(5), 2009.

 

G. Dumazer, C. Antoine, A. Lemarchand, and B. Nowakowski,

Steady dynamics of exothermic chemical wave fronts in van der Waals fluids,

Phys. Rev. E 80, 066309 (2009).

 

A. Estévez-Torres, T. Le Saux, C. Gosse, A. Lemarchand, A. Bourdoncle and L. Jullien,

Fourier Transform to Analyse Reaction-Diffusion Dynamics in a Microsystem,

Lab Chip 8, 1205 (2008).

 

G. Dumazer, M. Leda, B. Nowakowski, and A. Lemarchand,

Transition between an exothermic chemical wave front and a generic flame,

Phys. Rev. E 78, 016309 (2008).

 

H. Berthoumieux, L. Jullien, and A. Lemarchand,

Temporal modulation of a spatially periodic potential for kinetically governed oriented motion,

J. Phys. Chem. B 111, 2045 (2007).

 

A. Lemarchand and B. Nowakowski,

Internal fluctuations in a thermochemical system: excitability, oscillations and coherence resonances,

J. Phys.: Condens. Matter 19, 065130 (2007).

 

C. Antoine and A. Lemarchand,

Resonance of relaxation time in the temperature modulated Schlögl model,

J. Chem. Phys. 126, 104103 (2007).

 

M. Leda, A. Lemarchand and B. Nowakowski,

Forbidden interval of propagation speed for exothermic chemical fronts,

Phys. Rev. E 75, 056304 (2007).

 

A. Estevez-Torres, C. Gosse, T. Le Saux, J.-F. Allemand, V. Croquette, H. Berthoumieux, A. Lemarchand, L. Jullien, 

Fourier analysis to measure diffusion coefficients and resolve mixtures on a continuous electrophoresis chip,

Anal. Chem. 79, 8222 (2007).

 

A. Lemarchand and J.-P. Bonnet,

Modeling silicon carbide synthesis on a submicrometric scale,

J. Phys. Chem. C 111, 10829 (2007).

 

B. Nowakowski and A. Lemarchand,

Sensitivity of an exothermic chemical wave front to a departure from local equilibrium,

J. Chem. Phys. 127, 174712 (2007).

 

H. Berthoumieux, L. Jullien, and A. Lemarchand,

Response to a temperature modulation as a signature of the chemical mechanism,

Phys. Rev. E 76, 056112 (2007).

Selected by the Virtual Journal of Biological Physics Research, Nov. 15, Vol. 14(10), 2007.

 

J.-C. Nièpce et al.,

Main recent contributions in SHS from France,

Int. J. SHS 16, 235 (2007).

 

A. Lemarchand and J.-P. Bonnet,

Modelling silicon carbide formation during heating at constant rate,

J. Eur. Ceram. Soc. 26, 2389 (2006).

 

J. S. Hansen, B. Nowakowski and A. Lemarchand,

Molecular dynamics simulations and master-equation description of a chemical wave front: effects of density and size of reaction zone on propagation speed,

J. Chem. Phys. 124, 034503 (2006).

 

J. S. Hansen and A. Lemarchand,

Mixing of nanofluids: a molecular dynamics simulation and modelling,

Mol. Simulat. 32, 419 (2006).

 

J. S. Hansen, B. Nowakowski and A. Lemarchand,

Microscopic simulations of an exothermic chemical wave front: departure from the continuity equations,

J. Chem. Phys. 125, 044313 (2006).

 

D. Alcor, J.-F. Allemand, E. Cogné-Laage, V. Croquette, F. Ferrage, L. Jullien, A. Kononov, and A. Lemarchand,

Stochastic resonance to control diffusive motion in chemistry,

J. Phys. Chem. B 109, 1318 (2005).

 

A. Lemarchand and B. Nowakowski,

Coherence resonances in an autonomous thermochemical model with internal fluctuations,

Europhys. Lett. 71, 530 (2005).

 

A. Lemarchand and L. Jullien,

Symmetry-broken reactant motion upon phase-related symmetrically modulated excitations : application to highly selective molecular sorting,

J. Phys. Chem. A 109, 5770 (2005).

 

S. Charier, A. Meglio, D. Alcor, E. Cogné-Laage, J.-F. Allemand, L. Jullien, A. Lemarchand,

Reactant concentrations from fluorescence correlation spectroscopy with tailored fluorescent probes. An example of local calibration-free pH measurement,

J. Am. Chem. Soc. 127, 15491 (2005).

 

J. S. Hansen, J. Ottesen and A. Lemarchand,

Molecular dynamics simulations of valveless pumping in a closed microfluidic tube-system,

Mol. Simulat. 31, 963 (2005).

 

A. Lemarchand and L. Jullien,

Tuning a reaction using two-site catalysis and far-from-equilibrium conditions,

Phys. Chem. Chem. Phys. 6, 398 (2004).

 

A. Lemarchand and L. Jullien,

Competition and symbiosis in a chemical world,

J. Phys. Chem. B 108, 11782 (2004).

 

A. Lemarchand and B. Nowakowski,

Enhanced sensitivity of a thermochemical system to microscopic perturbations,

Physica A 331, 409 (2004).

 

M. Nicollet, A. Lemarchand, and N. Cavaciuti,

Detection of atmospheric turbulence by multifractal analysis using wavelets,

Fractals 12, 211 (2004).

 

D. Alcor, V. Croquette, L. Jullien, and A. Lemarchand,

Molecular sorting by stochastic resonance,

Proc. Nat. Acad. Sci. USA 101, 8276 (2004).

 

A. Lemarchand and B. Nowakowski,

Fluctuation-induced and nonequilibrium-induced bifurcations in a thermochemical system,

Mol. Simulat. 30, 773 (2004).

 

D. Alcor, J.-F. Allemand, I . Aujard, J.-B. Baudin, C. Benbrahim, S. Charier, E. Cogné-Laage, V. Croquette, A. Estevez-Torres, F. Ferrage, L. Jullien, A. Kononov, A. Lemarchand, H. Lemarchand, O. Ruel,

Controlled assembly of covalent and supramolecular chemical modules: from engineering of complex structures to high-performance chromatography,

Russ. Chem. Bull. 53, 1379 (2004).

 

B. Nowakowski and A. Lemarchand

Sensitivity of explosion to departure from partial equilibrium,

Phys. Rev. E 68, 031105 (2003).

 

L. Jullien, A. Lemarchand, S. Charier, O. Ruel, and J.-B. Baudin,

Two-site molecules as a road for engineering complexity in chemical systems,

J. Phys. Chem. B 107, 9905 (2003).

 

B. Nowakowski, A. Lemarchand, and E. Nowakowska,

Stochastic effects in the bistable homogeneous Semenov model,

Acta Physica Polonica B, 33, 1031 (2002).

 

L. Jullien and A. Lemarchand,

Evaluation of the separation efficiency of some processes based on interaction of reactive species with a static, spatially periodic potential,

J. Phys. Chem. B 105, 4415 (2001).

 

B. Nowakowski and A. Lemarchand,

Stochastic effects in a thermochemical system with Newtonian cooling,

Phys. Rev. E 64, 061108 (2001).

 

B. Nowakowski, A. Lemarchand, and E. Nowakowska,

Non standard reaction kinetics: microscopic simulations of a system with product removal,

Chem. Phys. 270, 287 (2001).

 

A. Lemarchand,

Selection of an attractor in a continuum of stable solutions: descriptions of a wave front at different scales,

J. Stat. Phys. 101, 579 (2000).

 

M. Nicollet, A. Lemarchand, and G.M.L. Dumas,

Singularity spectrum of non periodic time series: surrogate data and wavelet transform,

Fractals 8, 129 (2000).

 

A. Lemarchand and B. Nowakowski,

Macroscopic effects of the perturbation of particle velocity distribution in a trigger wave,

Phys. Rev. E 62, 3156 (2000).

 

L. Jullien, A. Lemarchand, and H. Lemarchand,

Diffusion of reactive species tuned by modulated external field: application to high performance chromatography,

J. Chem. Phys. 112, 8293 (2000).

 

A. Lemarchand and B. Nowakowski,

Perturbation of Particle Velocity Distribution in a Bistable Chemical System,

Physica A 271, 87 (1999).

 

O. Bénichou, A. -M. Cazabat, A. Lemarchand, M. Moreau, and G. Oshanin,

Biased Diffusion in a One Dimensional Adsorbed Monolayer,

J. Stat. Phys. 97, 351 (1999).

 

A. Lemarchand and B. Nowakowski,

Different description levels of chemical wave front and propagation speed selection,

J. Chem. Phys. 111, 6190 (1999).

 

A. Lemarchand and B. Nowakowski,

Microscopic Simulation of a Wave Front: Chemically Induced Perturbation of Particle Velocity Distribution,

Europhys. Lett. 41, 455 (1998).

 

A. Lemarchand, B. Nowakowski, and A. Karzazi,

Non Equilibrium Effects in Chemical Wave Fronts: Microscopic Simulations and Analytical Approach,

Acta Physica Polonica B 29, 1623 (1998).

 

A. Lemarchand and B. Nowakowski,

Perturbation of Local Equilibrium by a Chemical Wave Front,

J. Chem. Phys. 109, 7028 (1998).

 

M. Nicollet, A. Lemarchand, and G.M.L. Dumas,

Wavelet Transform of a Multifractal Measure in a Cool Flame Experiment,

Fractals 5, 35 (1997).

 

B. Nowakowski and A. Lemarchand,

Effect of Chemical Reaction on Diffusion of Diluted Gas: Simulations by Means of Two Monte Carlo Methods,

J. Chem. Phys. 106, 3965 (1997).

 

A. Lemarchand and M. Mareschal,

A Lattice-Gas Model for a Reaction-Diffusion System,

in Computer Simulation in Materials Science, eds. H.O. Kirchner et al, p. 259, Kluwer, Netherlands (1996).

 

M. Mareschal and A. Lemarchand,

Cellular Automata and Mesoscale Simulations,

in Computer Simulation in Materials Science, eds. H.O. Kirchner et al, p. 85, Kluwer, Netherlands (1996).

 

I. Nainville, A. Lemarchand, and J. -P. Badiali,

Growth Dynamics and Morphology of Passive Films,

Phys. Rev. E 53, 2537 (1996).

 

I. Nainville, A. Lemarchand, and J. -P. Badiali,

Growth and Morphology of Thick Films Formed on a Metallic Surface,

Electrochimica Acta 41, 1855 (1996).

 

I. Nainville, A. Lemarchand, and J. -P. Badiali,

Passivation of a Lithium Anode: a Simulation Model,

Electrochimica Acta 41, 2855 (1996).

 

A. Lemarchand, I. Nainville, and M. Mareschal,

Fractal Dimension of Reaction-Diffusion Wave Fronts,

Europhys. Lett. 36, 227 (1996).

 

A. Karzazi, A. Lemarchand, and M. Mareschal,

Fluctuation Effects on Chemical Wave Fronts,

Phys. Rev. E 54, 4888 (1996).

 

A. Lemarchand, A. Lesne, and M. Mareschal,

Langevin Approach to a Chemical Wave Front: Selection of the Propagation Velocity in Presence of Internal Noise,

Phys. Rev. E 51, 4457 (1995).

 

A. Lemarchand, M. Nicollet, and G.M.L. Dumas,

Diffusion-Induced Chaos in a Cool Flame Experiment,

Rev. Gen. Therm. 34 (403-404), 437 (1995).

 

A. Lemarchand, A. Lesne, A. Perera, M. Moreau, and M. Mareschal,

Chemical Wave Front in Two Dimensions,

Phys. Rev. E 48, 1568 (1993).

 

A. Lemarchand, H. Lemarchand, and M. Mareschal,

Microscopic Simulation of a Wave Front Propagating into an Unstable State: Internal Fluctuation Effects,

Solid State Phenomena 23-24, 49 (1992).

 

A. Lemarchand, H. Lemarchand, E. Sulpice, and M. Mareschal,

Microscopic Simulation of a Wave Front: Fluctuation Effects on Propagation Velocity and Width

Physica A 188, 277 (1992).

 

E. Sulpice, A. Lemarchand, and H. Lemarchand,

Normal Form of Stochastic Equations for Chemical Systems near Bifurcation Points,

Phys. Lett. A 158, 43 (1991).

 

A. Lemarchand, R.I. Ben Aïm, and G. Nicolis,

Experimental Study of Sensitivity of Thermal Explosion,

Chem. Phys. Lett. 162, 92 (1989).

 

A. Lemarchand, H. Lemarchand, and E. Sulpice,

Interaction of a Hopf Bifurcation and a Symmetry-Breaking Bifurcation: Stochastic Potential and Spatial Correlations,

J. Stat. Phys. 53, 613 (1988).

 

E. Sulpice, A. Lemarchand, and H. Lemarchand,

Non-Analytic Stochastic Potential for a Local Codimension-Two Bifurcation,

Phys. Lett. A 121, 67 (1987).

 

A. Fraikin and H. Lemarchand,

Stochastic Analysis of a Hopf Bifurcation,

J. Stat. Phys. 41, 531 (1985).

 

Software

 

Inventors A. Lemarchand and V. Narayan

Software GYPSY, Simulation de la dissolution du plâtre et de la croissance du gypse à une échelle submicrométrique,

(simulation of plaster hydration and gypsum growth at a submicrometric scale)

registered on May 28, 2015 at Agence de Protection des Programmes (APP):

IDDN.FR.001.230009.000.S.P.2015.000.30630

 

 

Patents

 

Process for determining the reaction mechanism of a reaction and associated device

Inventors C. Gosse, A. Lemarchand, L. Jullien, T. Le Saux, K. Zrelli

International patent EP2788115 (A1) , WO2013083725 (A1), US20140370611

owned by CNRS, Publication Date: June 13, 2013 Number PCT/EP2012/074699

 

Procédé de détermination du mécanisme réactionnel dune réaction et dispositif associé

Inventors: C. Gosse, A. Lemarchand, L. Jullien, T. Le Saux, K. Zrelli

French patent, application number FR1161290, December 7, 2011

 

Method for separating a chemical or biological compound in a mixture of similar compounds by diffusion in a medium such as a gel

Inventors: L. Jullien, H. Lemarchand, A. Lemarchand

International patent DE60025839T2, EP1224455A1, EP1224455B1, US20030036503, WO2001031325 (A1), US6893546 (B2)

owned by CNRS, Publication Date: May 3, 2001

 

Enhancing electrophoretic separation of similar chemical or biological compounds, by applying alternating field tuned for selective promotion of molecular mobility

Inventors: L. Jullien, H. Lemarchand, A. Lemarchand

French patent FR2799988, owned by CNRS, Publication Date: April 27, 2001