**Annie Lemarchand Fraikin**

Directrice de recherche au CNRS

Habilitée à diriger des recherches

**Contact**

Université Pierre et Marie Curie

Laboratoire de Physique Théorique de la Matière Condensée – CNRS UMR 7600

4 place Jussieu, case courrier 121

75252 Paris cedex 05, FRANCE

Corridor 13-23, 5th floor, room 507

Tel: 33 (0)1 44 27 44 55

Fax: 33 (0)1 44 27 51 00

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

**Research domain**

**Multiscale description of far-from-equilibrium chemical systems**

At the interface between statistical physics, dynamical systems applied to chemistry, and materials science, my research activities concentrate on the multiscale study of the dynamics and structure of far-from-equilibrium reactive systems.

The following issues are presently investigated:

- Modeling of somitogenesis (formation of prevertebrae) using Turing-like structures at the macroscopic, mesoscopic and microscopic scales. Emphasis is given on the constructive role of internal fluctuations,

- Modeling of cell interactions in the framework of thermostatted kinetic theory with application to the interactions between cancer cells and immune-system cells,

- Kinetic Monte Carlo simulations of plaster hydration and gypsum precipitation : development of a predictive tool in order to rationalize the choice of additives and the optimization of material properties,

- In collaboration with experimentalists in microfluidics, design of non-invasive methods of

(i) determination of chemical mechanisms and rate constants for chemical and biological reaction networks,

(ii) distinction between a nonequilibrium steady state and an equilibrium state.

**Evaluation of the departure from equilibrium at cell scale**

Carlo Bianca and Annie Lemarchand

J. Chem. Phys. **141**, 144102 (2014),
Physica A **438**, 1 (2015)

The complex spatio-temporal structures that appear in biological systems require far-from equilibrium conditions which lead to the circulation of reaction fluxes. Recent developments in nonequilibrium statistical physics propose a theoretical framework for estimating these reaction fluxes. In particular, the time asymmetry of fluctuations could be* a priori* exploited. Fluorescence imaging gives directly access to the observation of the dynamics of cell events. The temporal ordering of three proteins in the endocytic pathway has been extracted and reaction flux has been estimated for an assumed mechanism with linear dynamics [D. R. Sisan, D. Yarar, C. M. Waterman, and J. S. Urbach, Biophys. J. **98**, 2432 (2010)]. However, endocytosis is known to involve complex regulation mechanisms and our aim is to warn against the blind use of the simple relation between reaction flux and cross-correlation function of concentration fluctuations found for linear deterministic dynamics [W. J. Heuett and H. Qian, J. Chem. Phys. **124**, 044110 (2006)].

In the biologically relevant case of a reactive system which may admit periodic oscillations, our results show that the amplitude of the cross-correlation functions is not only proportional to the reaction flux but also to a specific parameter-dependent function which diverges as a Hopf bifurcation approaches. In order to harvest the determination of correlation functions for reaction flux estimation in a given chemical system, it is therefore essential first to identify the reaction mechanism and secondly to evaluate the associated rate constants. If these demanding requirements may be fulfilled, the stochastic differential equations of Langevin type governing the fluctuating dynamics of concentrations provide a reliable, analytical formula relating the reaction flux and the correlations of fluctuations. From the theoretical viewpoint, the interplay between fluctuations and nonlinearities of deterministic dynamics is subtle and leads to specific formulas for the time cross-correlations of concentration fluctuations, that depend on the details of dynamics.

**Publications**

C. Bianca and A. Lemarchand,

*Miming the cancer-immune system competition by kinetic Monte Carlo simulations,*

J. Chem. Phys. to appear.

L. Signon, B. Nowakowski, and A. Lemarchand,

*Modelling somite scaling in small embryos in the framework of Turing patterns*,

Phys. Rev. E **93**, 042402 (2016).

J. Quérard, T. Le Saux, A. Gautier, D. Alcor, V. Croquette, C. Gosse, A. Lemarchand, and L. Jullien,

*Kinetics of reactive modules adds discriminative dimensions for selective cell imaging*,

ChemPhysChem **17**, 1396 (2016).

J. Gorecki, B. Nowakowski, J. N. Gorecka, and A. Lemarchand,

*Minimum size for a nanoscale temperature discriminator based on a thermochemical sy**stem**,*

Phys. Chem. Chem. Phys.
**18**, 4952 (2016).

C. Bianca and A. Lemarchand,

*From cellular to tissue scales by asymptotic limits of thermostatted kinetic models*,

Eur. Phys. J. Plus **131**, 41 (2016).

C. Bianca and A. Lemarchand,

*Evaluation of reaction fluxes in stationary and oscillating far-from-equilibrium biological systems*,

Physica A **438**, 1 (2015).

F. Closa, C. Gosse, L. Jullien, and A. Lemarchand,

*Identication of two-step chemical mechanisms using small temperature oscillations and a single tagged species*,

J. Chem. Phys. **142**, 174108 (2015).

C. Bianca, C. Dogbe, and A. Lemarchand,

*Onset of hyperbolic macroscopic behavior in complex systems subjected to external agents*,

Appl. Math. Inf. Sci. **9**, 2477 (2015).

C. Bianca and A. Lemarchand,

*Density evolution by the low-field limit of kinetic frameworks with thermostat and mutations*,

Commun. Nonlinear Sci. Numer. Simulat. **20**, 14 (2015).

C. Bianca, C. Dogbe, and A. Lemarchand,

*The role of nonconservative interactions in the asymptotic limit of thermostatted kinetic models*,

Acta Appl. Math. **139**, 1 (2015).

S. Joiret, F. Pillier, and A. Lemarchand,

*Submicrometric Picture of Plaster Hydration: Dynamic and Space-Resolved Raman Spectroscopy versus Kinetic Monte Carlo Simulations*,

J. Phys. Chem. C **118**, 28730 (2014).

C. Bianca, L. Guerrini, and A. Lemarchand,

*Existence of solutions of a partial integro-differential equation with thermostat and time delay*,

Abstract and Applied Analysis **2014**, 463409 (2014).

C. Bianca and A. Lemarchand,

*Determination of reaction flux from concentration fluctuations near a Hopf bifurcation*,

J. Chem. Phys. **141**, 144102 (2014).

C. Bianca and A. Lemarchand,

*Temporal cross-correlation asymmetry and departure from equilibrium in a bistable chemical system*,

J Chem. Phys. **140**, 224105 (2014).

C. Bianca and A. Lemarchand,

*A Kinetic Framework for Modeling Nonequilibrium Biological and Chemical Systems, *

Nonlinear Stud. **21**, 367 (2014).

A. Lemarchand, J. Gorecki, A. Gorecki, and B. Nowakowski,

*Temperature driven coherence resonance and stochastic resonance in a thermochemical system, *

Phys. Rev. E **89**, 022916 (2014).

P. Dziekan, L. Signon, B. Nowakowski, and A. Lemarchand,

*Effect of a local source or sink of inhibitor on Turing patterns, *

Commun. Theor. Phys. **62**, 622 (2014).

P. Dziekan, B. Nowakowski, and A. Lemarchand,

*Reaction-diffusion scheme for the clock and wavefront mechanism of pattern formation*,

Eur. Phys. J. B **87**, 77 (2014).

J. Gorecki, A. Gorecki, A. Lemarchand, and B. Nowakowski,

*Information resonance in a model excitable system*,

Eur. Phys. J. B **86**, 264 (2013).

P. Dziekan, L. Signon, B. Nowakowski, and A. Lemarchand,

*Reaction-diffusion approach to prevertebrae formation: Effect of a local source of morphogen*,

J Chem. Phys. **139,** 114107 (2013).

F. Closa, C. Gosse, L. Jullien, and A. Lemarchand,

*Identification of Two-Step Chemical Mechanisms and Determination of Thermokinetic Parameters using Frequency Responses to Small Temperature Oscillations, *

J Chem. Phys. **138**, 244109 (2013).

C. Antoine, G. Dumazer, B. Nowakowski, and A. Lemarchand,

*Nonlinear** **hydrodynamic** **corrections** **to** **supersonic** **F-KPP** **wave** **fronts*,

Physica D **241**, 461 (2012).

P. Dziekan, A. Lemarchand, and B. Nowakowski,

*Master** **equation** **for** **a** **bistable** **chemical** **system** **with** **perturbed** particle **velocity** **distribution** **function*,

Phys. Rev E **85**, 021128 (2012).

A. Lemarchand, F. Boudoire, E. Boucard, T. Chotard, and A. Smith,

*Plaster** **hydration** **at** **different** **plaster-to-water** **ratios:** **Acoustic** **emission** **and** **3-dimensional** **submicrometric** **simulations,** *

J. Phys. Chem. C **116**, 4671 (2012).

A. Lemarchand, H. Berthoumieux, L. Jullien, and C. Gosse,

*Chemical** **mechanism** **identification** **from** **frequency** **response** **to** **small** **temperature** **modulation*,

J. Phys. Chem. A **116**, 8455 (2012).

P. Dziekan, A. Lemarchand, and B. Nowakowski,

*Particle dynamics simulations of Turing patterns,*

J. Chem. Phys. **137**, 074107 (2012).

P. Dziekan, B. Nowakowski, and A. Lemarchand,

*Master** **equation** **for** **a** **chemical** **wave** **front** **with** **perturbation** **of** **local** **equilibrium*,

J. Chem. Phys. **135**, 084123 (2011).

Selected by the Virtual Journal of Nanoscale Science & Technology, Sept. 12, Vol. 24(11), 2011.

K. Zrelli, T. Barilero, H. Berthoumieux, T. Le Saux, C. Gosse, A. Lemarchand and L. Jullien,

*Kinetic** **and** **Thermodynamic** **Characterisation** **by** **Heating** **in** **a** **Microfluidic** **Cell*,

Sensor Lett. **9**, 2332 (2011).

A. Lemarchand, B. Nowakowski, G. Dumazer, and C. Antoine,

*Microscopic** **simulations** **of** **supersonic** **and** **subsonic** **exothermic** **chemical** **wave** **fronts** **and** **transition** **to** **detonation*,

J. Chem. Phys. **134**, 034121 (2011).

K. Zrelli, T. Barilero, E. Cavatore, H. Berthoumieux, T. Le Saux, V. Croquette, A. Lemarchand, C. Gosse, and L. Jullien,

*Temperature** **modulation** **and** **quadrature** **detection** **for** **selective** **titration** **of** **two-state** **exchanging** **reactants*,

Anal. Chem. **83**, 2476 (2011).

A. Lemarchand and B. Nowakowski,

*Do** **the** **internal** **fluctuations** **blur** **or** **enhance** **axial** **segmentation?,** *

EuroPhysics Letters **94**, 48004 (2011).

B. Nowakowski, A. L. Kawczynski, A. Kolbus, and A. Lemarchand,

*Coherence** **resonances** **in** **excitable** **thermochemical** **systems** **induced** **by** **scaled** **reaction** **heat*,

Eur. Phys. J. B **84**, 137 (2011).

G. Dumazer, A. Smith, and A. Lemarchand,

*Master** **equation** **approach** **to** **gypsum** **needle** **crystallization*,

J. Phys. Chem. C **114**, 3830 (2010).

A. Kolbus, A. Lemarchand, A. Kawczynski, and B. Nowakowski,

*Coherence** **resonances** **in** **an** **excitable** **thermochemical** **system** **with** **multiple** **stationary** **states*,

Phys. Chem. Chem. Phys. **12**, 13224 (2010).

G. Dumazer, V. Narayan, A. Smith, and A. Lemarchand,

*Modeling** **gypsum** **crystallization** **on** **a** **submicrometric** **scale*,

J. Phys. Chem. C **113**, 1189 (2009).

H. Berthoumieux, C. Antoine, L. Jullien, and A. Lemarchand,

*Resonant** **Response** **to** **Temperature** **Modulation** **for** **Enzymatic** **Dynamics** **Characterization*,

Phys. Rev. E **79**, 021906 (2009).

Selected by the Virtual Journal of Biological Physics Research, Feb. 15, Vol. 17(4), 2009.

H. Berthoumieux, C. Antoine, and A. Lemarchand,

*D**etermination** **of** **the** **six** **rate** **constants** **of** **a** **three-state** **enzymatic** **network** **and** **a** **noninvasive** **test** **of** **detailed** **balance*,

J. Chem. Phys. **131**, 084106 (2009).

Selected by the Virtual Journal of Biological Physics Research, Sep. 1, Vol. 18(5), 2009.

G. Dumazer, C. Antoine, A. Lemarchand, and B. Nowakowski,

*Steady** **dynamics** **of** **exothermic** **chemical** **wave** **fronts** **in** **van** **der** **Waals** **fluids*,

Phys. Rev. E **80**, 066309 (2009).

A. Estévez-Torres,^{ }T. Le Saux, C. Gosse, A. Lemarchand,^{ }A. Bourdoncle^{ }and L. Jullien,

*Fourier** **Transform** **to** **Analyse** **Reaction-Diffusion** **Dynamics** **in** **a** **Microsystem*,

Lab Chip **8**, 1205 (2008).

G. Dumazer, M. Leda, B. Nowakowski, and A. Lemarchand,

*Transition** **between** **an** **exothermic** **chemical** **wave** **front** **and** **a** **generic** **flame*,

Phys. Rev. E **78**, 016309 (2008).

H. Berthoumieux, L. Jullien, and A. Lemarchand,

*Temporal** **modulation** **of** **a** **spatially** **periodic** **potential** **for** **kinetically** **governed** **oriented** **motion,*

J. Phys. Chem. B **111**, 2045 (2007).

A. Lemarchand and B. Nowakowski,

*Internal fluctuations in a thermochemical system: excitability, oscillations and coherence resonances,*

J. Phys.: Condens. Matter **19**, 065130 (2007).

C. Antoine and A. Lemarchand,

*Resonance** **of** **relaxation** **time** **in** **the** **temperature** **modulated** **Schlögl** **model*,

J. Chem. Phys. **126**, 104103 (2007).

M. Leda, A. Lemarchand and B. Nowakowski,

*Forbidden** **interval** **of** **propagation** **speed** **for** **exothermic** **chemical** **fronts*,

Phys. Rev. E **75**, 056304 (2007).

A. Estevez-Torres, C. Gosse, T. Le Saux, J.-F. Allemand, V. Croquette, H. Berthoumieux, A. Lemarchand, L. Jullien,

*Fourier** **analysis** **to** **measure** **diffusion** **coefficients** **and** **resolve** **mixtures** **on** **a** **continuous** **electrophoresis** *chip,

Anal. Chem. **79**, 8222 (2007).

A. Lemarchand and J.-P. Bonnet,

*Modeling** **silicon** **carbide** **synthesis** **on** **a** **submicrometric** **scale*,

J. Phys. Chem. C **111**, 10829 (2007).

B. Nowakowski and A. Lemarchand,

*Sensitivity** **of** **an** **exothermic** **chemical** **wave** **front** **to** **a** **departure** **from** **local** **equilibrium*,

J. Chem. Phys. **127**, 174712 (2007).

H. Berthoumieux, L. Jullien, and A. Lemarchand,

*Response** **to** **a** **temperature** **modulation** **as** **a** **signature** **of** **the** **chemical** **mechanism*,

Phys. Rev. E **76**, 056112 (2007).

Selected by the Virtual Journal of Biological Physics Research, Nov. 15, Vol. 14(10), 2007.

J.-C. Nièpce et al.,

*Main** **recent** **contributions** **in** **SHS** **from** **France*,

Int. J. SHS **16**, 235 (2007).

A. Lemarchand and J.-P. Bonnet,

*Modelling** **silicon** **carbide** **formation** **during** **heating** **at** **constant** **rate,*

J. Eur. Ceram. Soc. **26**, 2389 (2006).

J. S. Hansen, B. Nowakowski and A. Lemarchand,

*Molecular** **dynamics** **simulations** **and** **master-equation** **description** **of** **a** **chemical** **wave** **front:** **effects** **of** **density** **and** **size** **of** **reaction** **zone** **on** **propagation** **speed,*

J. Chem. Phys. **124,** 034503 (2006).

J. S. Hansen and A. Lemarchand,

*Mixing** **of** **nanofluids:** **a** **molecular** **dynamics** **simulation** **and** **modelling,*

Mol. Simulat. **32**, 419 (2006).

J. S. Hansen, B. Nowakowski and A. Lemarchand,

*Microscopic** **simulations** **of** **an** **exothermic** **chemical** **wave** **front:** **departure** **from** **the** **continuity** **equations,*

J. Chem. Phys. **125**, 044313 (2006).

D. Alcor, J.-F. Allemand, E. Cogné-Laage, V. Croquette, F. Ferrage, L. Jullien, A. Kononov, and A. Lemarchand,

*Stochastic** **resonance** **to** **control** **diffusive** **motion** **in** **chemistry,*

J. Phys. Chem. B **109**, 1318 (2005).

A. Lemarchand and B. Nowakowski,

*Coherence** **resonances** **in** **an** **autonomous** **thermochemical** **model** **with** **internal** **fluctuations,*

Europhys. Lett. **71**, 530 (2005).

A. Lemarchand and L. Jullien,

*Symmetry-broken** **reactant** **motion** **upon** **phase-related** **symmetrically** **modulated** **excitations :** **application** **to** **highly** **selective** **molecular** **sorting*,

J. Phys. Chem. A **109**, 5770 (2005).

S. Charier, A. Meglio, D. Alcor, E. Cogné-Laage, J.-F. Allemand, L. Jullien, A. Lemarchand,

*Reactant** **concentrations** **from** **fluorescence** **correlation** **spectroscopy** **with** **tailored** **fluorescent** **probes.** **An** **example** **of** **local** **calibration-free** **pH** **measurement*,

J. Am. Chem. Soc. **127**, 15491 (2005).

J. S. Hansen, J. Ottesen and A. Lemarchand,

*Molecular** **dynamics** **simulations** **of** **valveless** **pumping** **in** **a** **closed** **microfluidic** **tube-system*,

Mol. Simulat. **31**, 963 (2005).

A. Lemarchand and L. Jullien,

*Tuning** **a** **reaction** **using** **two-site** **catalysis** **and** **far-from-equilibrium** **conditions,*

Phys. Chem. Chem. Phys. **6**, 398** **(2004).

A. Lemarchand and L. Jullien,

*Competition** **and** **symbiosis** **in** **a** **chemical** **world,*

J. Phys. Chem. B **108**, 11782 (2004).

A. Lemarchand and B. Nowakowski,

*Enhanced** **sensitivity** **of** **a** **thermochemical** **system** **to** **microscopic** **perturbations,*

Physica A **331**, 409 (2004).

M. Nicollet, A. Lemarchand, and N. Cavaciuti,

*Detection** **of** **atmospheric** **turbulence** **by** **multifractal** **analysis** **using** **wavelets,*

Fractals **12**, 211 (2004).

D. Alcor, V. Croquette, L. Jullien, and A. Lemarchand,

*Molecular** **sorting** **by** **stochastic** **resonance,*

Proc. Nat. Acad. Sci. USA **101**, 8276 (2004).

A. Lemarchand and B. Nowakowski,

*Fluctuation-induced** **and** **nonequilibrium-induced** **bifurcations** **in** **a** **thermochemical** **system,*

Mol. Simulat. **30**, 773 (2004).

D. Alcor, J.-F. Allemand, I . Aujard, J.-B. Baudin, C. Benbrahim, S. Charier, E. Cogné-Laage, V. Croquette, A. Estevez-Torres, F. Ferrage, L. Jullien, A. Kononov, A. Lemarchand, H. Lemarchand, O. Ruel,

*Controlled** **assembly** **of** **covalent** **and** **supramolecular** **chemical** **modules:** **from** **engineering** **of** **complex** **structures** **to** **high-performance** **chromatography,*

Russ. Chem. Bull. **53**, 1379 (2004).

B. Nowakowski and A. Lemarchand

Sensitivity of explosion to departure from partial equilibrium,

Phys. Rev. E **68**, 031105 (2003).

L. Jullien, A. Lemarchand, S. Charier, O. Ruel, and J.-B. Baudin,

*Two-site** **molecules** **as** **a** **road** **for** **engineering** **complexity** **in** **chemical** **systems,*

J. Phys. Chem. B **107**, 9905 (2003).

B. Nowakowski, A. Lemarchand, and E. Nowakowska,

*Stochastic effects in the bistable homogeneous Semenov model,*

Acta Physica Polonica B, **33**, 1031 (2002).

L. Jullien and A. Lemarchand,

*Evaluation** **of** **the** **separation** **efficiency** **of** **some** **processes** **based** **on** **interaction** **of** **reactive** **species** **with** **a** **static,** **spatially** **periodic** **potential*,

J. Phys. Chem. B **105**, 4415 (2001).

B. Nowakowski and A. Lemarchand,

*Stochastic** **effects** **in** **a** **thermochemical** **system** **with** **Newtonian** **cooling,*

Phys. Rev. E **64**, 061108 (2001).

B. Nowakowski, A. Lemarchand, and E. Nowakowska,

*Non standard reaction kinetics: microscopic simulations of a system with product removal,*

Chem. Phys. **270**, 287 (2001).

A. Lemarchand,

*Selection** **of** **an** **attractor** **in** **a** **continuum** **of** **stable** **solutions:** **descriptions** **of** **a** **wave** **front** **at** **different** **scale*s,

J. Stat. Phys. **101**, 579 (2000).

M. Nicollet, A. Lemarchand, and G.M.L. Dumas,

*Singularity** **spectrum** **of** **non** **periodic** **time** **series:** **surrogate** **data** **and** **wavelet** **transform*,

Fractals **8**, 129 (2000).

A. Lemarchand and B. Nowakowski,

*Macroscopic** **effects** **of** **the** **perturbation** **of** **particle** **velocity** **distribution** **in** **a** **trigger** **wave*,

Phys. Rev. E **62**, 3156 (2000).

L. Jullien, A. Lemarchand, and H. Lemarchand,

*Diffusion** **of** **reactive** **species** **tuned** **by** **modulated** **external** **field:** **application** **to** **high** **performance** **chromatography*,

J. Chem. Phys. **112**, 8293 (2000).

A. Lemarchand and B. Nowakowski,

*Perturbation** **of** **Particle** **Velocity** **Distribution** **in** **a** **Bistable** **Chemical** **System*,

Physica A **271**, 87 (1999).

O. Bénichou, A. -M. Cazabat, A. Lemarchand, M. Moreau, and G. Oshanin,

*Biased** **Diffusion** **in** **a** **One** **Dimensional** **Adsorbed** **Monolayer*,

J. Stat. Phys. **97**, 351 (1999).

A. Lemarchand and B. Nowakowski,

Different description levels of chemical wave front and propagation speed selection,

J. Chem. Phys. **111**, 6190 (1999).

A. Lemarchand and B. Nowakowski,

*Microscopic** **Simulation** **of** **a** **Wave** **Front:** **Chemically** **Induced** **Perturbation** **of** **Particle** **Velocity** **Distribution*,

Europhys. Lett. **41**, 455 (1998).

A. Lemarchand, B. Nowakowski, and A. Karzazi,

*Non** **Equilibrium** **Effects** **in** **Chemical** **Wave** **Fronts:** **Microscopic** **Simulations** **and** **Analytical** **Approach*,

Acta Physica Polonica B **29**, 1623 (1998).

A. Lemarchand and B. Nowakowski,

*Perturbation** **of** **Local** **Equilibrium** **by** **a** **Chemical** **Wave** **Front*,

J. Chem. Phys. **109**, 7028 (1998).

M. Nicollet, A. Lemarchand, and G.M.L. Dumas,

*Wavelet** **Transform** **of** **a** **Multifractal** **Measure** **in** **a** **Cool** **Flame** **Experiment*,

Fractals **5**, 35 (1997).

B. Nowakowski and A. Lemarchand,

*Effect** **of** **Chemical** **Reaction** **on** **Diffusion** **of** **Diluted** **Gas:** **Simulations** **by** **Means** **of** **Two** **Monte** **Carlo** **Methods*,

J. Chem. Phys. **106**, 3965 (1997).

A. Lemarchand and M. Mareschal,

*A** **Lattice-Gas** **Model** **for** **a** **Reaction-Diffusion** **System*,

in Computer Simulation in Materials Science, eds. H.O. Kirchner et al, p. 259, Kluwer, Netherlands (1996).

M. Mareschal and A. Lemarchand,

*Cellular** **Automata** **and** **Mesoscale** **Simulations*,

in Computer Simulation in Materials Science, eds. H.O. Kirchner et al, p. 85, Kluwer, Netherlands (1996).

I. Nainville, A. Lemarchand, and J. -P. Badiali,

*Growth** **Dynamics** **and** **Morphology** **of** **Passive** **Films*,

Phys. Rev. E **53**, 2537 (1996).

I. Nainville, A. Lemarchand, and J. -P. Badiali,

*Growth** **and** **Morphology** **of** **Thick** **Films** **Formed** **on** **a** **Metallic** **Surface*,

Electrochimica Acta **41**, 1855 (1996).

I. Nainville, A. Lemarchand, and J. -P. Badiali,

*Passivation** **of** **a** **Lithium** **Anode:** **a** **Simulation** **Model*,

Electrochimica Acta **41**, 2855 (1996).

A. Lemarchand, I. Nainville, and M. Mareschal,

*Fractal** **Dimension** **of** **Reaction-Diffusion** **Wave** **Fronts*,

Europhys. Lett. **36**, 227 (1996).

A. Karzazi, A. Lemarchand, and M. Mareschal,

*Fluctuation** **Effects** **on** **Chemical** **Wave** **Fronts*,

Phys. Rev. E **54**, 4888 (1996).

A. Lemarchand, A. Lesne, and M. Mareschal,

*Langevin** **Approach** **to** **a** **Chemical** **Wave** **Front:** **Selection** **of** **the** **Propagation** **Velocity** **in** **Presence** **of** **Internal** **Noise*,

Phys. Rev. E **51**, 4457 (1995).

A. Lemarchand, M. Nicollet, and G.M.L. Dumas,

*Diffusion-Induced** **Chaos** **in** **a** **Cool** **Flame** **Experiment*,

Rev. Gen. Therm. **34** (403-404), 437 (1995).

A. Lemarchand, A. Lesne, A. Perera, M. Moreau, and M. Mareschal,

*Chemical** **Wave** **Front** **in** **Two** **Dimensions*,

Phys. Rev. E **48**, 1568 (1993).

A. Lemarchand, H. Lemarchand, and M. Mareschal,

*Microscopic** **Simulation** **of** **a** **Wave** **Front** **Propagating** **into** **an** **Unstable** **State:** **Internal** **Fluctuation** **Effects*,

Solid State Phenomena **23-24**, 49 (1992).

A. Lemarchand, H. Lemarchand, E. Sulpice, and M. Mareschal,

*Microscopic** **Simulation** **of** **a** **Wave** **Front:** **Fluctuation** **Effects** **on** **Propagation** **Velocity** **and** **Width** *

Physica A **188**, 277 (1992).

E. Sulpice, A. Lemarchand, and H. Lemarchand,

*Normal** **Form** **of** **Stochastic** **Equations** **for** **Chemical** **Systems** **near** **Bifurcation** **Points*,

Phys. Lett. A **158**, 43 (1991).

A. Lemarchand, R.I. Ben Aïm, and G. Nicolis,

*Experimental** **Study** **of** **Sensitivity** **of** **Thermal** **Explosion*,

Chem. Phys. Lett. **162**, 92 (1989).

A. Lemarchand, H. Lemarchand, and E. Sulpice,

*Interaction** **of** **a** **Hopf** **Bifurcation** **and** **a** **Symmetry-Breaking** **Bifurcation:** **Stochastic** **Potential** **and** **Spatial** **Correlations*,

J. Stat. Phys. **53**, 613 (1988).

E. Sulpice, A. Lemarchand, and H. Lemarchand,

*Non-Analytic** **Stochastic** **Potential** **for** **a** **Local** **Codimension-Two** **Bifurcation*,

Phys. Lett. A **121**, 67 (1987).

A. Fraikin and H. Lemarchand,

*Stochastic** **Analysis** **of** **a** **Hopf** **Bifurcation*,

J. Stat. Phys. **41**, 531 (1985).

**Software**

Inventors A. Lemarchand and V. Narayan

Software GYPSY, *Simulation de la dissolution du plâtre et de la croissance du gypse à une échelle submicrométrique, *

*(simulation of plaster hydration and gypsum growth at a submicrometric scale)*

registered on May 28, 2015 at Agence de Protection des Programmes (APP):

IDDN.FR.001.230009.000.S.P.2015.000.30630

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***Patents**

*Process for determining the reaction mechanism of a reaction and associated device*

Inventors C. Gosse, A. Lemarchand, L. Jullien, T. Le Saux, K. Zrelli

International patent EP2788115 (A1) , WO2013083725 (A1), US20140370611

owned by CNRS, Publication Date: June 13, 2013 Number PCT/EP2012/074699

*Procédé de détermination du mécanisme réactionnel d’une réaction et dispositif associé*

Inventors: C. Gosse, A. Lemarchand, L. Jullien, T. Le Saux, K. Zrelli

French patent, application number FR1161290, December 7, 2011

*Method for separating a chemical or biological compound in a mixture of similar compounds by diffusion in a medium such as a gel*

Inventors: L. Jullien, H. Lemarchand, A. Lemarchand

International patent DE60025839T2, EP1224455A1, EP1224455B1, US20030036503, WO2001031325 (A1), US6893546 (B2)

owned by CNRS, Publication Date: May 3, 2001

*Enhancing electrophoretic separation of similar chemical or biological compounds, by applying alternating field tuned for selective promotion of molecular mobility *

Inventors: L. Jullien, H. Lemarchand, A. Lemarchand

French patent FR2799988, owned by CNRS, Publication Date: April 27, 2001