Doctor in Physics

Maitre de Conferences
Laboratoire de Physique Théorique de la Matière Condensée
Université Pierre et Marie Curie (Paris VI)

Laboratoire de Physique Theorique de la Matière Condensée
Université Pierre et Marie Curie (Paris VI)
4, Place Jussieu
75252 PARIS cedex 05
Tél (0)1 4427 2643 Fax (0)1 4427 5100

General data:
Place and date of birth: Florence (Italy), 20/12/1968.
Italian citizen.


Degree in Physics, with maximum degree and honors (110/110 cum laude), 11 July 1995, Universita' degli Studi di Pisa:
Advisor: Prof. Paolo Grigolini

Studio delle sequenze di DNA come processo statistico dinamico

Area of Research : Analysis of the statistical properties of DNA sequences as dynamical processes.

Ph.D. in Physics, 11 February 1999, Universita' degli Studi di Firenze:
Advisor: Prof. Stefano Ruffo

Localized solutions in a model of DNA helicoidal structure (pdf and ps.gz)

Area of Research : Dynamical modeling of the DNA molecule, physical basis of the transcription process.

Feb-Jul 1998: Visitor at Ecole Normale Superieure de Lyon. Collaboration with M. Peyrard, S. Cocco.

Post Doctoral Research Grant, 1999 - 2001, Universita' degli Studi di Salerno:
Tutor: Prof. Mario Salerno

Area of Research : Application of analitical thechniques and stochastic methods to biophysical and non linear systems.

Jan-Jul 2001: Visitor at Ecole Normale Superieure de Lyon. Research in protein and chromatin dynamics, collaboration with M. Peyrard, S. Lepri, B. Berge, C. Place.

Maitre de Conference since Sept. 2001, Laboratoire de Physique Theorique de la Matière Condensée of the Université Pierre et Marie Curie:

Area of Research : Dynamical modeling of protein DNA interactions.

Habilitation à diriger des recherches (HDR), Université Pierre et Marie Curie: December 2010, manuscipt


See here for a list of publication with direct links to on line papers and reprints


See here for a list of conferences with some presentations


I am interested in understanding the physical mechanisms underlying the functioning of biological systems, and especially to all processes involving DNA. The central theme that we develop in the team Multiscale Modeling of living matter (M3V group) is the study of the functional dynamics of the chromatin fiber.

I am particularly interested, in the recent years, in the topology of the chromatin fiber and its role in the interpretation of magnetic tweezers experiments zllowing to manipulte unique chromatin fibers. We hypothesized that a reversal of the nucleosome chirality, induced by the application of a torque, may give rise to a new nucleosome conformation, wound on the right, which we named the reversome.

This work also involved the introduction of new methods for performing simulation, especially developed by Pascal Carrivain during his PhD.

On the other hand, the M3V team has integrated following my arrival, a new line of research, namely the study of the mechanisms of searching for target sequences along the DNA adopted by proteins, and their involvement in the regulation of gene expression. This research line also open the way to the study of important electrostatic effects in chromatin organization.

Our group is also at the origin of the GDR Nuclear Organization and Dynamics (DNA), a CNRS research network including more than 80 French teams working in the broad field of nuclear architecture and functional dynamics of chromosomes.


You can ask for a reference the following persons:
  • Prof. Paolo Grigolini
  • Prof. Stefano Ruffo
  • Prof. Ludmila Yakushevich
  • Prof. Michel Peyrard
  • Prof. Mario Salerno
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